Apoptotic Protease-Activating Factor 1

A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.

Also Known As:

Apaf-1 Protease-Activating Factor; Apoptotic Peptidase Activating Factor 1; Apaf 1 Protease Activating Factor; Apoptotic Protease Activating Factor 1; Protease-Activating Factor, Apaf-1

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Apoptotic Protease-Activating Factor 1: 52
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - CARD Signaling Adaptor Proteins
        Apoptotic Protease-Activating Factor 1: 52
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Apoptotic Protease-Activating Factor 1: 52
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - CARD Signaling Adaptor Proteins
        Apoptotic Protease-Activating Factor 1: 52
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Apoptotic Protease-Activating Factor 1: 52

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Disease

Drug/Important Bio-Agent (IBA)